Theoph                  package:nls                  R Documentation

_P_h_a_r_m_a_c_o_k_i_n_e_t_i_c_s _o_f _t_h_e_o_p_h_y_l_l_i_n_e

_D_e_s_c_r_i_p_t_i_o_n:

     The `Theoph' data frame has 132 rows and 5 columns of data from an
     experiment on the pharmacokinetics of theophylline.

_F_o_r_m_a_t:

     This data frame contains the following columns:

     _S_u_b_j_e_c_t an ordered factor with levels `1', ..., `12'
            identifying the subject on whom the observation was made.
            The ordering is by increasing maximum concentration of
            theophylline observed.

     _W_t weight of the subject (kg).

     _D_o_s_e dose of theophylline administered orally to the
            subject (mg/kg).

     _T_i_m_e time since drug administration when the sample was
            drawn (hr).

     _c_o_n_c theophylline concentration in the sample (mg/L).

_D_e_t_a_i_l_s:

     Boeckmann, Sheiner and Beal (1994) report data from a study by Dr.
     Robert Upton of the kinetics of the anti-asthmatic drug
     theophylline. Twelve subjects were given oral doses of
     theophylline then serum concentrations were measured at 11 time
     points over the next 25 hours.

     These data are analyzed in Davidian and Giltinan (1995) and
     Pinheiro and Bates (2000) using a two-compartment open
     pharmacokinetic model, for which a self-starting model function,
     `SSfol', is available.

_S_o_u_r_c_e:

     Boeckmann, A. J., Sheiner, L. B. and Beal, S. L. (1994), NONMEM
     Users Guide: Part V, NONMEM Project Group, University of
     California, San Francisco.

     Davidian, M. and Giltinan, D. M. (1995) Nonlinear Models for
     Repeated Measurement Data, Chapman & Hall (section 5.5, p. 145 and
     section 6.6, p. 176)

     Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S
     and S-PLUS, Springer (Appendix A.29)

_S_e_e _A_l_s_o:

     `SSfol'

